Agilent Technologies G1978B Guia do Utilizador descarregar pdf (Página 58)

58 Multimode Source for 6100 Series Single Quad LC/MS User Guide

3 Reference

Guidelines

Guidelines for multimode source settings in MM-ES mode

Nebulizer pressure Always set to 60 psi.

Drying gas flow Always set to 5 L/min (IR does the drying).

Drying gas temperature Depends on the vaporizer temperature. A good

starting temperature is 250°C. If running a cold vaporizer temperature, then

set the drying gas temperature to vapor temperature or lower. If running the

vaporizer hot (>175°C), then set the drying gas temperature to 350°C.

Remember you want the vaporizer to control the drying and to be able to

maintain the set point.

Vaporizer Start at 150°C. ESI works across a broad vaporizer range. If you are

getting excessive sodium adducts, lower the temperature. You can run as low

as 60°C. It is recommend to run 100°C or greater. Negative ion TFA adducts

work best at lower temperature (<150°C).

Vcap Set to 2000 V. A lower voltage works better for fast switching. High

mass ions (>1000) prefer a higher Vcap.

Charging Voltage Set to 200 V.

NOTE

Click Instrument > MSD Spray Chamber to set the Method Spray Chamber to

MM-ES+APCI before you edit the Set Up MSD Signals dialog box.

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Agilent Technologies G1978B Guia do Utilizador Página 58